Association Between Complete Blood Count Parameters and Glycemic Control in Type 2 Diabetes Mellitus: A Descriptive Cross-Sectional Study
DOI:
https://doi.org/10.58600/eurjther2797Keywords:
glycemic control, HbA1c, hematological parameters, MCV, NLR, RDW, Type 2 diabetes mellitusAbstract
Objective: This study investigated the association between HbA1c levels and hematological parameters in patients with type 2 diabetes mellitus to determine their potential as markers of glycemic regulation.
Methods: This retrospective cross-sectional study included 498 patients with Type 2 diabetes mellitus attending the Endocrinology Outpatient Clinic of Selcuk University Faculty of Medicine between January 2023 and December 2024, along with 500 healthy adults as controls. Demographic data (age and sex) and laboratory results were retrospectively analyzed.
Results: HbA1c levels showed positive correlations with age (r = 0.558, p < 0.001), WBC (r = 0.237, p < 0.001), RDW (r = 0.128, p < 0.001), and NLR (r = 0.068, p = 0.040). An inverse association was detected between HbA1c levels and MCV (r = −0.238, p < 0.001). There were no statistically meaningful associations identified between HbA1c levels and MPV, PLT, or Hgb
(p > 0.05). Among individuals with type 2 diabetes, WBC, RDW and NLR were notably elevated, whereas MCV was significantly reduced in comparison to the control group (p < 0.05).
Conclusion: The observed associations between HbA1c and selected hematological parameters indicate that complete blood count—given its affordability and accessibility—may serve as a supportive tool for the assessment of glycemic status in patients with Type 2 diabetes mellitus. Parameters such as MCV, RDW, and NLR could act as potential biomarkers for glycemic control and early complication detection. However, these findings require validation through large-scale, multicenter, prospective studies.
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Copyright (c) 2025 Bahar Ürün Ünal, Esma Nakipoglu, Süleyman Baldane
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