The Predictive Value of the NAPLES Prognostic Score for Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography
DOI:
https://doi.org/10.58600/eurjther3136Keywords:
chronic coronary syndrome, contrast-induced nephropathy, coronary angiography, NAPLES score, stable angina pectorisAbstract
Objective: Contrast-induced nephropathy (CIN) is a leading cause of morbidity and mortality in patients undergoing coronary angiography (CAG) and percutaneous coronary intervention (PCI). Although contrast exposure is common during CAG, reliable and practical predictors of CIN remain limited. The Naples Prognostic Score (NAPLES score), reflecting inflammation and nutritional status, may serve as a potential marker. This study aimed to evaluate its association with CIN in patients with chronic coronary syndrome.
Methods: The study design was designed as a retrospective, sequential, hospital-based investigation. The present study was carried out on a total of 443 individuals diagnosed with chronic coronary syndrome (CCS) who had undergone CAG at Harran University Hospital between June 1, 2025, and January 1, 2026. The patients were grouped into two categories: those who developed CIN and those who did not. We compared the groups based on the patients’ demographic data, complete blood count results, main biochemical data, and NAPLES score.
Results: The study’s patient population included 443 patients, among whom CIN developed in 69 patients (15.6%). In the CIN (+) group, serum albumin and total cholesterol levels were significantly lower, whilst the prevalence of diabetes mellitus (DM) was higher. The NAPLES score showed a significant increase in the CIN (+) group (p < 0.001). The findings of this study indicated that patients with high NAPLES scores exhibited a significantly higher incidence of CIN compared to those with low NAPLES scores (29.7% vs. 5.4%, p < 0.001). Multivariate logistic regression analysis identified the NAPLES score as a robust and independent predictor of CIN development (OR=5,896, 95% CI:3.50–9.94, p < 0.001).
Conclusion: This study showed that the NAPLES score independently and strongly predicts CIN development in patients undergoing elective CAG due to CCS. The nearly 6-fold increase in the risk of CIN development among patients with high NAPLES scores underscores the efficacy of this score as a practical tool for pre-contrast risk stratification.
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